A novel maize variety designated X80P535 and seed, plants and plant parts thereof are produced by crossing inbred maize varieties. Methods for producing a maize plant by crossing hybrid maize variety X80P535 with another maize plant are disclosed. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into X80P535 through backcrossing or genetic transformation, and to the maize seed, plant and plant part produced thereby are described. Maize variety X80P535, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of maize variety X80P535 are provided. Methods for producing maize varieties derived from maize variety X80P535 and methods of using maize variety X80P535 are disclosed.