A serial receiver combines continuous-time equalization, analog interleaving, and discrete-time gain for rapid, efficient data reception and quantization of a serial, continuous-time signal. A continuous-time equalizer equalizes a received signal. A number N of time-interleaved analog samplers sample the equalized continuous-time signal to provide N streams of analog samples transitioning at rate reduced by 1/N relative to the received signal. A set of N discrete-time variable-gain amplifiers amplify respective streams of analog samples. A quantizer then quantizes the amplified streams of analog samples to produce a digital signal.