A sole structure for an article of footwear having an upper includes a heel region, a forefoot region, and a mid-foot region disposed between the heel region and the forefoot region. The sole structure also includes a fluid-filled chamber including a first barrier layer cooperating with a second barrier layer to define a fluid-filled segment extending along a medial side of the sole structure within the heel region, a second fluid-filled segment extending along a lateral side of the sole structure within the heel region, and a web area disposed between and connecting the first fluid-filled segment and the second fluid-filled segment. The first barrier layer is attached to the second barrier layer within the web area.