A method includes flowing an inlet solution having an inlet salinity and an inlet ion concentration from an inlet to a membrane filtration system, dynamically adjusting the salinity or ion concentration of the inlet solution in situ as the inlet solution flows to an inlet of a microfluidic cell, and determining a wettability alteration in situ while dynamically adjusting the salinity or ion concentration of the inlet solution. A system includes a fluid inlet, a microfluidic cell fluidly coupled to the fluid inlet, the microfluidic cell having a surface representative of a reservoir rock, and a membrane filtration system coupled between the microfluidic cell and the fluid inlet.