- 专利标题： T cell receptors that bind to mixed lineage leukemia (MLL)-specific phosphopeptides and methods of use thereof
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申请号： US16807742申请日： 2020-03-03
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公开(公告)号： US11718658B2公开(公告)日： 2023-08-08
- 发明人: Marc van Dijk , Ekaterina Vladimirovna Breous-Nystrom , Alessandra Franchino , Sébastien Lalevée , Arthur Andrew Hurwitz , Mark Adrian Exley , Benjamin Jacob Wolf
- 申请人： MiNK Therapeutics, Inc.
- 申请人地址： US NY New York
- 专利权人： MiNK Therapeutics, Inc.
- 当前专利权人： MiNK Therapeutics, Inc.
- 当前专利权人地址： US NY New York
- 代理机构： Wolf, Greenfield & Sacks, P.C.
- 主分类号： C07K14/725
- IPC分类号： C07K14/725 ; C12N15/63 ; A61K38/00 ; A61K45/06
摘要：
Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
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