Systems and methods for volume control over intercom trunk lines. One example method includes receiving, from a first keypanel coupled to a first intercom, a call request identifying a remote keypanel coupled to a second intercom. The method includes transmitting a trunk request based on the call request and receiving a trunk setup message. The method includes activating a first crosspoint to provide a two-way audio connection between the first and second intercom devices. The method includes applying a trunk gain value to the first crosspoint based on the remote keypanel and transmitting, with an audio gain based on the trunk gain value, an audio stream received from the first keypanel. The method includes receiving, from the second intercom, a gain adjustment value associated with the first keypanel and the remote keypanel and applying an adjusted trunk gain value to the first crosspoint based on the gain adjustment value.