- 专利标题： CAL-T constructs and uses thereof
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申请号： US17072490申请日： 2020-10-16
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公开(公告)号： US11723950B2公开(公告)日： 2023-08-15
- 发明人: Mohammadreza Pakyari , Wilson Wong , Atsushi Okuma , Curtis Cetrulo
- 申请人： TRUSTEES OF BOSTON UNIVERSITY , THE GENERAL HOSPITAL CORPORATION
- 申请人地址： US MA Boston
- 专利权人： TRUSTEES OF BOSTON UNIVERSITY,THE GENERAL HOSPITAL CORPORATION
- 当前专利权人： TRUSTEES OF BOSTON UNIVERSITY,THE GENERAL HOSPITAL CORPORATION
- 当前专利权人地址： US MA Boston; US MA Boston
- 代理机构： Nixon Peabody LLP
- 代理商 Ronald I. Eisenstein; Nicole D. Kling
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61K38/17 ; A61K39/44 ; C12N5/0783 ; C07K14/725 ; C07K14/47 ; A61K38/16 ; C12N15/10
摘要：
The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.
公开/授权文献
- US20210113653A1 CAL-T CONSTRUCTS AND USES THEREOF 公开/授权日：2021-04-22
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