Systems and methods are described for securing confidential content in a virtual meeting. In an example, a host can create a meeting agenda that identifies attendees and access restrictions for the meeting. A server can generate encryption keys corresponding to different confidentiality levels of content identified in the agenda. The encryption keys can be provided to user devices of the attendees based on the access permissions of the attendees. As the virtual meeting takes place, the server can encrypt confidential portions of the content stream for the meeting using the encryption keys. In an example, the server can also apply a machine learning algorithm to identify any confidential content in the content stream not previously identified. The server can encrypt additional confidential content where appropriate using encryption keys corresponding to the confidentiality level of the content.