A surgical instrument includes a body, a shaft assembly, and an end effector. The shaft assembly extends distally from the body. The end effector is located at a distal end portion of the shaft assembly. The end effector includes an active feature configured to operate on tissue. The body includes a drive feature operable to drive the active feature of the end effector. The body is removably coupled with the shaft assembly in a connected state and separated from the shaft assembly in a disconnected state. The body includes a drive feature configured to drive operation of the active feature of the effector. The drive feature includes at least one of an ultrasonic drive feature or a mechanical drive feature. A proximal end portion of the shaft assembly is configured to be removed from the body to separate the at least one activation feature from the drive feature.