Provided are systems and methods for text and audio-based real-time face reenactment. An example method includes receiving an input text and a target image, the target image including a target face; generating, based on the input text, a sequence of sets of acoustic features representing the input text; generating, based on the sequence of sets of acoustic features, a sequence of sets of mouth key points; generating, based on the sequence of sets of mouth key points, a sequence of sets of facial key points; generating, by the computing device and based on the sequence of sets of the facial key points and the target image, a sequence of frames; and generating, based on the sequence of frames, an output video. Each of the frames includes the target face modified based on at least one set of mouth key points of the sequence of sets of mouth key points.