A magnetic wheel driving device and a driving method using the same. The magnetic wheel driving device includes a vehicle body, a guide rail system, at least two magnetic wheel systems and a power system. The guide rail system includes two conductor plates, respectively arranged at two sides of the vehicle body. The at least two magnetic wheel systems are symmetrically arranged at two side walls of the vehicle body. A gap is provided between each magnetic wheel system and the corresponding conductor plate. The power system is configured to drive the at least two magnetic wheel systems to rotate.