A wheeled backpack includes a bottom frame member, a fabric bag portion, a pair of laterally spaced wheels, a pair of side frame members, and a telescoping handle that can move between a retracted position and an extended position where the handle can be grasped by a user to roll the backpack on the wheels. The handle is located so that there is little or no fore and aft offset of the center of mass/gravity of the backpack, which minimizes torquing on the handle and associated pivoting of the backpack in a user's hand when the backpack is lifted by the handle with the handle in the retracted position.