Various embodiments include methods and devices for compression and decompression of weight data sets. Some embodiments may include compressing weight data by receiving a weight data set of binary numbers representing weight values, generating a frame payload including a compressed first frame of a first subset of the weight values in the weight data set, and generating a block of compressed weight data having the frame payload. Some embodiments may include decompressing weight data by retrieving a block of compressed weight data, in which the block of compressed weight data includes a frame header associated with a frame payload, in which the frame header includes a normalization factor indicator, and in which the frame payload includes compressed weight values, and generating a first decompressed frame comprising decompressed weight values of the compressed weight values of the frame payload.