Provided are a display substrate and display apparatus. The display substrate includes a display region and non-display region; base substrate, driving structure layer and wiring layer. The driving structure layer located in the display region includes a first power supply line, data signal line and reference signal line extending along a first direction; the wiring layer located in the non-display region includes a first power supply wiring electrically connected to first power supply line and located on first side of the display region, a data wiring located on second side, different from the first side, of the display region, and a reference wiring located on second side of the display region. For the first power supply line, data signal line and reference signal line with the same length, resistance of first power supply line is greater than that of the data signal line and that of the reference signal line.