A care system for predicting bed exit and suitable for a frame supporting a patient is provided. The care system includes a boundary-crossing detection system, a location sensing system, and a control circuit. The boundary-crossing detection system is coupled with the frame. The location sensing system is coupled with the frame, and is for obtaining relative position information between the patient and the frame. The control circuit is for data communicating with the boundary-crossing detection system and the location sensing system, and is for accessing care data defining multiple bed-exit behaviors. When one of following situations occurs, the control circuit transmits a warning signal: (1) the control circuit determines that, according to the relative position information and the care data, a current behavior of the patient corresponds to one of the multiple bed-exit behaviors; and (2) the boundary-crossing detection system senses that an object is passing through.