Systems and techniques are provided for registering three-dimensional (3D) images to deformable models. An example method can include determining, based on an image of a target and associated depth information, a 3D mesh of the target; determining different sets of rotation and translation parameters based on modifications to rotation and translation parameters of the 3D mesh; generating, based on the different sets of rotation and translation parameters, different 3D meshes having different orientations, different poses, and/or different alignments relative to the target; determining different sets of model parameters associated with the different 3D meshes, based on modifications to the different sets of rotation and translation parameters; generating, based on the different sets of model parameters, different additional 3D meshes having different orientations, different poses, and/or different alignments relative to the target; and selecting a final 3D mesh of the target from the different additional 3D meshes.