Systems and methods for estimating a gaze vector of an eye using a trained neural network. An input image of the eye may be received from a camera. The input image may be provided to the neural network. Network output data may be generated using the neural network. The network output data may include two-dimensional (2D) pupil data, eye segmentation data, and/or cornea center data. The gaze vector may be computed based on the network output data. The neural network may be previously trained by providing a training input image to the neural network, generating training network output data, receiving ground-truth (GT) data, computing error data based on a difference between the training network output data and the GT data, and modifying the neural network based on the error data.