A display substrate and a manufacture method, and a display device are provided. The display substrate includes a shift register unit, a first clock signal line, and a second clock signal line. The shift register unit includes an input circuit, an output circuit, a first control circuit, a second control circuit, and a voltage stabilizing circuit. A first electrode of the first noise reduction transistor of the second control circuit and a first electrode of the voltage stabilizing transistor of the voltage stabilizing circuit are in a first source-drain electrode layer, which includes a first transfer electrode, which includes a first portion and a second portion, the first portion is connected to the first electrode of the first noise reduction transistor and the first electrode of the voltage stabilizing transistor, and the second portion is connected to the gate electrode of the first control transistor of the first control circuit.