A mechanical interlock system for a fluid filter is described herein. The mechanical interlock system may include a filter cartridge and a filter cartridge manifold for receiving the filter cartridge. The filter cartridge may include a filter body, a fluid inlet and outlet, and an integrated locking head. The integrated locking head may include a key extending radially outward from the integrated locking head and channels on an outer surface of the integrated locking head. The filter cartridge manifold may include an insertion and extraction tube for receiving the key and latching mechanisms. The insertion and extraction tube may include a primary keyway and a secondary keyway. The key, keyways, latching mechanisms, and/or channels may interact to maintain alignment of the filter cartridge during insertion of the filter cartridge into an appliance including the filter cartridge manifold.