The present application relates to the technical field of vehicle-mounted luggage, and discloses a vehicle-mounted luggage case with doors opening on both sides, including: a case bottom, a center-shaft split-type case lid, a lid opening mechanism, a power supply assembly and an electric control assembly, wherein an operation panel is provided on either side of the case bottom, a sealed compartment is provided at either end of the case bottom, a luggage compartment is formed between two sealed compartments, a bulkhead is formed on a side of the luggage compartment proximal to the two sealed compartments. The present application is not only provided with a center-shaft split-type case lid for convenient access, but can also effectively widen the size of the case bottom, and can open and close the lid electrically, which is more convenient to operate, and has the function of self-storing electric energy.