A panel driving circuit and a display device are provided. The panel driving circuit includes a control board and a plurality of driving modules. A plurality of first connectors and a plurality of first oblique-insertion-proof protection circuits are disposed on the control board. Each of the driving modules includes a driving circuit board and a plurality of driving chips. The driving circuit board is connected to the plurality of driving chips. A second connector and a second oblique-insertion-proof protection circuit are disposed on each of the driving circuit boards. Irreversible damage to displays caused by improper wiring insertion can be prevented.