A method and an apparatus for transmitting and receiving an uplink signal in a wireless communication system. A method of transmitting an uplink signal includes receiving configuration information related to a sounding reference signal (SRS) from a base station; and transmitting the SRS to the base station in one or more SRS resources in a SRS resource set configured by the configuration information. Based on time domain bundling between the SRS and an uplink demodulation reference signal (DMRS) being indicated, the SRS and the uplink DMRS are transmitted on the same antenna port and/or with the same spatial domain transmission filter.