Invention Grant
- Patent Title: ASH1L degraders and methods of treatment therewith
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Application No.: US17468308Application Date: 2021-09-07
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Publication No.: US11786602B2Publication Date: 2023-10-17
- Inventor: Jolanta Grembecka , Szymon Klossowski , Jing Deng , Tomasz Cierpicki , Hao Li , Hongzhi Miao , Trupta Purohit , EunGi Kim , Dong Chen
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Current Assignee Address: US MI Ann Arbor
- Agency: CASIMIR JONES, SC
- Agent David W. Staple
- Main IPC: A61K47/64
- IPC: A61K47/64 ; A61K31/404 ; A61K31/454 ; A61K31/4545 ; A61K35/02 ; A61K38/45 ; C07D309/24 ; C07D471/04 ; A61K9/00 ; A61P35/02 ; A61K47/54 ; C07D209/24
Abstract:
Provided herein are small molecules comprising a first domain that binds to ASH1L and a second domain that facilitates ASH1L degradation. In particular, ASH1L-targeting proteolysis targeting chimeras (PROTACs) and methods of use thereof for the treatment of disease (e.g., acute leukemia, solid cancers and other diseases dependent on activity of ASH1L) are provided.
Public/Granted literature
- US11633490B2 ASH1L degraders and methods of treatment therewith Public/Granted day:2023-04-25
Information query
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