Invention Grant
- Patent Title: Pyrazolopyridine derivatives and uses thereof
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Application No.: US17693759Application Date: 2022-03-14
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Publication No.: US11787785B2Publication Date: 2023-10-17
- Inventor: Simone Bonazzi , Artiom Cernijenko , Jennifer Stroka Cobb , Natalie Alysia Dales , Janetta Dewhurst , Matthew James Hesse , Rama Jain , John Ryan Kerrigan , Hasnain Ahmed Malik , James R. Manning , Gary O'Brien , Andrew W. Patterson , Noel Marie-France Thomsen , Pamela Y F Ting
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Adil R. Zhugralin
- Main IPC: C07D403/14
- IPC: C07D403/14 ; A61P7/00 ; C07D405/14 ; C07D417/14
Abstract:
The present disclosure relates to compounds of formula (I) and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.
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