Invention Grant
- Patent Title: Diagnosis and therapy of cancer involving cancer stem cells
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Application No.: US16795468Application Date: 2020-02-19
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Publication No.: US11795218B2Publication Date: 2023-10-24
- Inventor: Ugur Sahin , Ozlem Tureci , Korden Walter , Meike Wagner , Maria Kreuzberg , Sabine Hacker , Stefan Jacobs
- Applicant: BioNTech AG , Ganymed Pharmaceuticals GmbH , TRON—Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz
- Applicant Address: DE Mainz
- Assignee: BioNTech AG,Astellas Pharma Inc.,TRON—Translationale Onkologie an der Universität
- Current Assignee: BioNTech AG,Astellas Pharma Inc.,TRON—Translationale Onkologie an der Universität
- Current Assignee Address: DE Mainz; JP Tokyo; DE Mainz
- Agency: Neal, Gerber & Eisenberg LLP
- Priority: WO TEP2014066330 2014.07.30
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A61K31/337 ; A61K31/5365 ; A61K31/7048 ; A61K31/7064 ; A61K33/243 ; C07K16/30 ; A61K47/68 ; G01N33/574 ; A61N5/10 ; A61K39/00
Abstract:
The present invention provides methods for diagnosis or treatment of cancer diseases involving cancer stem cells comprising targeting CLDN6. In particular, the present invention provides a method of determining cancer stem cells comprising detecting cells expressing CLDN6. Furthermore, the present invention provides a method of treating or preventing cancer comprising inhibiting and/or eliminating cancer stem cells by administering an antibody having the ability of binding to CLDN6 to a cancer patient.
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