Invention Grant
- Patent Title: Antagonistic CD40 monoclonal antibodies and uses thereof
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Application No.: US17670223Application Date: 2022-02-11
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Publication No.: US11795231B2Publication Date: 2023-10-24
- Inventor: Aaron Yamniuk , Mary Struthers , Stanley R. Krystek, Jr. , Akbar Nayeem , Ginger Rakestraw
- Applicant: Bristol-Myers Squibb Company
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: Banner & Witcoff, LTD.
- The original application number of the division: US17080626 2020.10.26
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C07K16/28 ; A61K39/395 ; A61K47/68 ; C07K16/46 ; A61P37/00 ; A61K45/06 ; A61K39/00 ; C07K14/705

Abstract:
The disclosure provides for antibodies that bind CD40, including a humanized antibody. The antibodies bind CD40 and do not exhibit CD40 agonist activity. The antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells. Compositions comprising antibodies, methods of use for treatment of diseases involving CD40 activity, and use in the preparation of a medicament for treatment of a disease involving CD40 activity are provided.
Public/Granted literature
- US20220169742A1 ANTAGONISTIC CD40 MONOCLONAL ANTIBODIES AND USES THEREOF Public/Granted day:2022-06-02
Information query
IPC分类: