Systems and methods for initializing a robot to autonomously travel a route are disclosed. In some exemplary implementations, a robot can detect an initialization object and then determine its position relative to that initialization object. The robot can then learn a route by user demonstration, where the robot associates actions along that route with positions relative to the initialization object. The robot can later detect the initialization object again and determine its position relative to that initialization object. The robot can then autonomously navigate the learned route, performing actions associated with positions relative to the initialization object.