Invention Grant
- Patent Title: Compositions, methods and uses for thermally stable multi-targeted antigens
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Application No.: US17665285Application Date: 2022-02-04
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Publication No.: US11806432B2Publication Date: 2023-11-07
- Inventor: Theodore Randolph , Robert Garcea
- Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
- Applicant Address: US CO Denver
- Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
- Current Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
- Current Assignee Address: US CO Denver
- Agency: Polsinelli PC
- Main IPC: A61K9/16
- IPC: A61K9/16 ; A61K9/19 ; C12N7/00 ; A61K39/12 ; A61K39/295 ; A61K45/06 ; A61K39/00

Abstract:
Embodiments of the present invention provide for novel compositions and methods for making and using a thermally stable human papilloma virus (HPV) formulation or other stabilized multimeric virus formulation. Certain embodiments concern lyophilizing HPV formulations in the presence or absence of adjuvants. Other embodiments concern lypophilizing HPV capsomere vaccines in order to increase stability of an immunogenic composition against HPV infection for storage, delivery and use. In yet other embodiments, a single immunogenic composition can include a thermally stable formulation of multiple virus serotypes. Yet other embodiments disclosed herein concern multi-targeted antigen complexes lyophilized in formulations of use to prolong stability and/or enhance immunogenicity. Other embodiments concern exposing lyophilized multi-targeted antigen complexes to elevated temperatures to enhance immunogenicity of the antigens of the complex to multiple pathogens.
Public/Granted literature
- US20220175907A1 COMPOSITIONS, METHODS AND USES FOR THERMALLY STABLE MULTI-TARGETED ANTIGENS Public/Granted day:2022-06-09
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