In some examples, a conduit system includes a conduit defining a conduit lumen configured to provide a flow path for a fluid between a container and a medical machine. A flexible member secured to the conduit is configured to substantially occlude (e.g., close) the conduit lumen when deformed by a force acting on the flexible member toward the lumen. The conduit system includes a clamp head configured to pass through an opening defined by the conduit and exert the force on the flexible member, such that the flexible member occludes the conduit lumen. In examples, the conduit is substantially rigid conduit configured to provide a relatively constant geometry and/or flow path for the discharge of a nozzle.