A droplet infection suppression system includes an airflow generator capable of generating an airflow for separating a space into first regions, a first detector that detects human presence in each of the first regions, a second detector that detects coughing or sneezing in the space, and a controller which, when the second detector detects coughing or sneezing, controls the airflow generator to generate an airflow such that a second region including one or more first regions including a first region where human presence has been detected by the first detector is separated by the airflow from other regions.