- 专利标题： Poly-glutamine androgen receptor knock-in mouse models, reagents and methods
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申请号： US15940387申请日： 2018-03-29
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公开(公告)号： US11825820B2公开(公告)日： 2023-11-28
- 发明人: Mark Trifiro , Miltiadis Paliouras , Lenore K. Beitel , Carlos Alvarado
- 申请人： Mark Trifiro , Miltiadis Paliouras , Lenore K. Beitel , Carlos Alvarado
- 申请人地址： CA Montreal
- 专利权人： Mark Trifiro,Miltiadis Paliouras,Lenore K. Beitel,Carlos Alvarado
- 当前专利权人： Mark Trifiro,Miltiadis Paliouras,Lenore K. Beitel,Carlos Alvarado
- 当前专利权人地址： CA Montreal
- 代理机构： BENOIT & COTE INC.
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C07K14/72
摘要：
A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.
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