A device cold plasma sterilization includes a housing, a base, a conveying assembly, a plurality of core modules, a transformer, a control cabinet, a distribution box, a shielding door, and a controller. The housing is disposed on the base. The plurality of core modules is disposed in the housing along a moving direction of the conveying assembly and are spaced apart from each other. The plurality of core modules each include a plurality of electrode assemblies spaced from one another by equal distance and arranged in a row. The transformer, the control cabinet, and the distribution box are disposed in a lower part of the base and are connected to the plurality of electrode assemblies. The conveying assembly is disposed in a middle part of the base. The base includes an inlet for entry and an outlet for exit of a package to be sterilized.