发明授权
- 专利标题： PRMT5 inhibitors
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申请号： US17552016申请日： 2021-12-15
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公开(公告)号： US11845760B2公开(公告)日： 2023-12-19
- 发明人: Shon Booker , Matthew Paul Bourbeau , John R. Butler , Sanne Ormholt Schroder Glad , Brian Alan Lanman , Patricia Lopez , Francesco Manoni , Liping H. Pettus , Ian Sarvary , Nuria A. Tamayo , Mikkel Vestergaard , Nicholas Anthony Weires
- 申请人： AMGEN INC.
- 申请人地址： US CA Thousand Oaks
- 专利权人： AMGEN INC.
- 当前专利权人： AMGEN INC.
- 当前专利权人地址： US CA Thousand Oaks
- 代理商 Olga Mekhovich
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D471/14 ; C07D491/04 ; C07D491/14 ; C07D495/04 ; A61K31/4355 ; A61K31/436 ; A61K31/4365 ; A61K31/437 ; A61K31/4375 ; A61P35/00 ; C07D491/06 ; C07D471/06 ; C07D471/16 ; C07D491/16
摘要：
Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders. Compounds of Formula I have the following structure:
公开/授权文献
- US20220194955A1 NOVEL PRMT5 INHIBITORS 公开/授权日：2022-06-23
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