A vehicle power supply system mounted on a vehicle is provided. The vehicle power supply system includes a main battery, a power converting apparatus configured to convert DC power of the main battery into AC power, a switch configured to switch a state between energization and cutoff between the main battery and the power converting apparatus, a first DC-DC converter connected to a power supply wiring between the switch and the power converting apparatus, and a second DC-DC converter connected to a power supply wiring between the switch and the main battery. The first DC-DC converter and the second DC-DC converter are mounted at positions distant from each other in the vehicle.