A radical scavenger, a manufacturing method therefor, a membrane-electrode assembly including the radical scavenger, and a fuel cell including the membrane-electrode assembly are disclosed. The membrane-electrode assembly contains an ion exchange membrane; catalyst electrodes disposed on both surfaces of the ion exchange membrane, respectively; and a radical scavenger disposed at any one position selected from the group consisting of in the catalyst electrodes, in the ion exchange membrane, between the ion exchange membrane and the catalyst electrodes, and a combination thereof.