System and method embodiments are disclosed for high availability management for open radio access network (O-RAN). The O-RAN may be deployed on cloud with the O-CU deployed on a region cloud, O-RUs deployed on a cell site O-Cloud, and O-DUs deployed on an edge cloud. Each O-RU may comprise one or more RF clusters, computation clusters, and interface clusters. O-RU instances and O-DU instances may be instantiated with redundancy on the cell site O-Cloud and on the edge cloud, respectively, to serve one or more users. Local and central high-availability (HA) managers may be used to monitor O-RU instance performance for failure prediction/detection and to monitor internal states of each O-DU instance. In response to O-RU instance failure or O-DU internal states beyond/below state thresholds, new O-RU or O-DU instances may be instantiated as replacement instances for O-Cloud high availability management.