- 专利标题： Modulators of Cystic Fibrosis Transmembrane Conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
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申请号： US17323267申请日： 2021-05-18
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公开(公告)号： US11866450B2公开(公告)日： 2024-01-09
- 发明人: Jeremy J. Clemens , Alexander Russell Abela , Corey Don Anderson , Brett B. Busch , Weichao George Chen , Thomas Cleveland , Timothy Richard Coon , Bryan Frieman , Senait G. Ghirmai , Peter Grootenhuis , Anton V. Gulevich , Sara Sabina Hadida Ruah , Clara Kuang-Ju Hsia , Ping Kang , Haripada Khatuya , Jason McCartney , Mark Thomas Miller , Prasuna Paraselli , Fabrice Pierre , Sara E. Swift , Andreas Termin , Johnny Uy , Carl V. Vogel , Jinglan Zhou
- 申请人： Vertex Pharmaceuticals Incorporated
- 申请人地址： US MA Boston
- 专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人： Vertex Pharmaceuticals Incorporated
- 当前专利权人地址： US MA Boston
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- 分案原申请号： US16276350 2019.02.14
- 主分类号： C07D513/22
- IPC分类号： C07D513/22 ; A61K31/439 ; A61P11/00 ; A61K31/47 ; A61K31/404 ; C07D515/22
摘要：
Compounds of Formula (I):
pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.
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