Non-aqueous pesticidal macrolide compositions are provided which comprise (A) a major amount of at least one non-aqueous solvent selected from a glycol ether and a lactimide; (B) a minor amount of a mixture of (i) at least one pesticide selected from abamectin and emamectin benzoate, and (ii) optionally, at least one surfactant. In one embodiment, the at least one pesticide selected from abamectin and emamectin benzoate is present in the composition in an amount of at least 7% by weight. In another embodiment, the compositions of the invention are chemically stable. The compositions of the invention can be used directly as a concentrate for treating or reducing tree pest infestations by trunk injection or with dilution in water for control of pests in crops of useful plants.