A method of preparing antimicrobial material sheets suitable for manufacturing a wide range of products having antimicrobial properties. In exemplary embodiments, a fabric having antimicrobial agents may be calendered with a polymer such as a silicone compound or an elastomer, in order to create a fused material sheet that contains the antibacterial properties of the fabric. In exemplary embodiments, the antimicrobial agent is copper, a copper alloy, silver, a silver alloy, or other suitable antimicrobial agent from which a fabric may be created. In some exemplary embodiments, an uncured silicone composition and copper alloy fabric are calendered to obtain an antimicrobial material sheet suitable for compression molding a wide range of products. In some exemplary embodiments, an uncured silicone composition and copper alloy fabric are calendered and roto-cured to obtain a cured antimicrobial material sheet or sheet rolls that maybe suitable for die-cutting.