Invention Grant
- Patent Title: Cell line which is knock out the bmp receptor genes and a method of producing target proteins using the same
-
Application No.: US16556725Application Date: 2019-08-30
-
Publication No.: US11873326B2Publication Date: 2024-01-16
- Inventor: Gyun-Min Lee , Che Lin Kim
- Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Applicant Address: KR Daejeon
- Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
- Current Assignee Address: KR Daejeon
- Agency: Sheridan Ross P.C.
- Priority: KR 20190018104 2019.02.15
- Main IPC: C07K14/51
- IPC: C07K14/51 ; C12N15/10 ; C12N15/113
Abstract:
The present invention relates to a transgenic CHO cell line in which the BMP receptor gene BMPRIA or BMPRII is knocked out. The BMP type I receptor BMPRIA or BMP type II receptor BMPRII gene which plays an important role in intracellular signal transduction in CHO cells is knocked out to prevent the activation of self concentration control pathway and the signal transduction mediated by BMP in CHO cells, so that the productivity of a target protein to be produced can be improved.
Public/Granted literature
Information query
