In a general aspect, radio frequency (RF) electromagnetic radiation can be detected using vapor cell sensors. In some aspects, a system includes a laser system that is configured to generate laser signals that comprise first and second laser signals. The system also includes an optical comb generator and a vapor cell sensor. The optical comb generator is configured to generate a comb spectrum based on the first laser signal. The comb spectrum includes comb lines at respective comb frequencies. The vapor cell sensor contains a vapor and is configured to generate an optical spectrum based on interactions of the vapor with the comb spectrum and the second laser signal. The system also includes an optical detector that is configured to detect the property of the optical spectrum at one or more of the comb frequencies.