Provided are a drive module, a voltage generation method thereof, and a display device. The drive module includes a mainboard, a power chip, and a driver chip. The driver chip includes a main control unit and a base voltage generation unit. The main control unit is configured to determine the target value of a base voltage in the current drive display mode according to the current drive display mode, determine the optimal voltage multiplying relationship of the base voltage in the current drive display mode according to an analog reference voltage signal and the target value of the base voltage, calculate the actual output value of the base voltage according to the analog reference voltage signal and the optimal voltage multiplying relationship, and generate first instruction information including the actual output value. The base voltage generation unit generates the corresponding base voltage according to the first instruction information.