- 专利标题： Anti-epidermal growth factor receptor variant III chimeric antigen receptors and use of same for the treatment of cancer
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申请号： US17410129申请日： 2021-08-24
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公开(公告)号： US11879017B2公开(公告)日： 2024-01-23
- 发明人: Richard A Morgan , Steven A. Rosenberg
- 申请人： The United States of America,as represented by the Secretary,Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The United States of America, as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 代理机构： Leydig, Voit & Mayer
- 分案原申请号： US14994403 2016.01.13
- 主分类号： C07K16/32
- IPC分类号： C07K16/32 ; G01N33/574 ; C07K14/705 ; C07K14/725 ; C07K16/30 ; A61K39/00 ; C07K16/28 ; A61K48/00 ; A61K38/00
摘要：
The invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
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