It is difficult to construct an optical fiber transmission system enabling relay optical amplification using a coupled multi-core optical fiber as an optical transmission path; therefore, an optical amplification device includes first optical spatial layout converting means for converting a spatial layout of a plurality of optical signal beams propagating through each of a plurality of cores, from a coupled state in which optical signal beams interfere between a plurality of cores to a non-coupled state in which optical signal beam interference is reduced between a plurality of cores; optical amplifying means for amplifying, in the non-coupled state, the plurality of optical signal beams with the non-coupled state and generating a plurality of amplified optical signal beams; and second optical spatial layout converting means for converting a spatial layout of the plurality of amplified optical signal beams from the non-coupled state to the coupled state.