Invention Grant
- Patent Title: Substituted pyrimido[1,2-b]pyridazines as positive allosteric modulators of the muscarinic acetylcholine receptor M
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Application No.: US18187868Application Date: 2023-03-22
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Publication No.: US11884676B2Publication Date: 2024-01-30
- Inventor: Craig W. Lindsley , P. Jeffrey Conn , Darren W. Engers , Alison R. Gregro , Kayla J. Temple , Madeline F. Long , Anna E. Ringuette , Logan A. Baker , Thomas Jensen
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- Main IPC: A61K31/519
- IPC: A61K31/519 ; C07D487/04
![Substituted pyrimido[1,2-b]pyridazines as positive allosteric modulators of the muscarinic acetylcholine receptor M](/abs-image/US/2024/01/30/US11884676B2/abs.jpg.150x150.jpg)
Abstract:
Disclosed herein are analogues of 6-(4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)oxy)piperidin-1 -yl)-[1,2,4]triazolo[4,3-b]pyridazine of formula (Ib), which may be useful as positive allosteric modulators of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions.
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