An optical sensor may include a housing, a printed circuit board, an optical emitter, and an optical detector. The housing can define a channel configured to receive a transparent tubing line through which fluid can flow during operation. The housing can have multiple optical pathways, including a primary optical pathway transecting the channel, a light emission optical pathway, and a light detection optical pathway. The optical emitter and optical detector can each be mounted on the printed circuit board. Further, the housing may be positioned on the printed circuit board with the optical emitter aligned to emit light into the light emission optical pathway and the optical detector aligned to receive light from the light detection optical pathway.