One embodiment of the present invention relates to a method and a device for transmitting and receiving a signal in a wireless communication system, the method comprising the steps of: performing a random access procedure; monitoring a physical downlink control channel (PDCCH) for an ON duration on the basis of a configured discontinuous reception (DRX) operation after performing the random access procedure; and operating an inactivity timer on the basis of the successfully received PDCCH for the ON duration. During the random access procedure, a random access preamble is transmitted in one or two physical random access channel (PRACH) slots. The one or two PRACH slots are determined from among N slots corresponding to a reference slot. A subcarrier spacing (SCS) setting value for the reference slot may be 2 on the basis of the SCS setting value applied to the N slots being 5 or 6.