- 专利标题： Modified complex platform of adeno-associated virus with improved rate of expression of loaded genes and reduced genotoxicity
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申请号： US18190630申请日： 2023-03-27
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公开(公告)号： US11891617B1公开(公告)日： 2024-02-06
- 发明人: Suk Chul Bae , You Soub Lee , Xinzi Chi , Tae Geun Park , Woo-Jin Kim
- 申请人： GENECRAFT INC.
- 申请人地址： KR Cheongju-si
- 专利权人： GENECRAFT INC.
- 当前专利权人： GENECRAFT INC.
- 当前专利权人地址： KR Cheongju-si
- 代理机构： Crowell & Moring LLP
- 主分类号： C12N7/01
- IPC分类号： C12N7/01 ; C12N15/86
摘要：
Described herein is an adeno-associated virus (AAV) complex platform including an asymmetrically modified inverted terminal repeat (ITR). The AAV complex has advantages of increased productivity and expression efficiency of a transgene, and decreased genotoxicity, by having an asymmetric ITR in which any one of two ITRs is modified. Also, described herein is a composition comprising the adeno-associated virus complex and a method of gene therapy.
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