Invention Grant
- Patent Title: Evaluation, assays and treatment of pKal-mediated disorders
-
Application No.: US16881911Application Date: 2020-05-22
-
Publication No.: US11892450B2Publication Date: 2024-02-06
- Inventor: Kusumam Joseph , Allen P. Kaplan
- Applicant: Takeda Pharmaceutical Company Limited
- Applicant Address: JP Osaka
- Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee: Takeda Pharmaceutical Company Limited
- Current Assignee Address: JP Osaka
- Agency: Wolf, Greenfield & Sacks, P.C.
- The original application number of the division: US14761671
- Main IPC: G01N33/53
- IPC: G01N33/53 ; G01N33/573 ; C12Q1/37 ; G01N33/68 ; C07K16/38 ; C07K14/435 ; C07K16/40

Abstract:
The invention provides assay methods of detecting plasma protease CI inhibitor (C1-INH) that binds plasma kallikrein, Factor XII, or both, and uses thereof for identifying subjects at risk for or suffering from a pKal-me-diated or bradykinin-mediated disorder. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment.
Information query
IPC分类: