Invention Grant
- Patent Title: Polynucleotides encoding rituximab-resistant chimeric antigen receptors
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Application No.: US16857573Application Date: 2020-04-24
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Publication No.: US11896617B2Publication Date: 2024-02-13
- Inventor: Thomas Charles Pertel , Barbra Johnson Sasu , Mark W. Leonard
- Applicant: ALLOGENE THERAPEUTICS, INC.
- Applicant Address: US CA South San Francisco
- Assignee: ALLOGENE THERAPEUTICS, INC.
- Current Assignee: ALLOGENE THERAPEUTICS, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Allogene Therapeutics, Inc.
- Main IPC: C12N15/62
- IPC: C12N15/62 ; A61K35/17 ; A61P35/00 ; C07K14/705 ; C07K16/28 ; C12N5/0783 ; A61K39/00
Abstract:
Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD19 antigen binding domain that specifically binds to CD19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD19-specific CARs, and immune cells comprising these CD19-specific CARs.
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